Acetyl Tetrapeptide-5 can reduce vascular permeability, thereby reducing water accumulation in eyelid tissue. It can also inhibit ACE (Angiotensin Converting Enzyme) activity, inhibit angiotensin II and relieve vascular pressure, so as to improve eye bags and dark circles. In addition, it can also inhibit glycosylation and reduce collagen cross-linking, so as to reduce eye bags and anti wrinkle. Therefore, it can be recommended in eye care products to alleviate edema and improve eye bags and dark circles.